Professional/ Research Background
| Duration (Date) | Name of Project | Position | Institution |
| 1.10.2008-30.09.2010 | To determine the relevance of anti-cyclic citrullinated peptide (anti-CCP) antibody in the diagnosis of Early Rheumatoid Arthritis and its clinically significant cut-off titre in our population | Junior Research Fellow | IPGME&R, S.S.K.M. Hospital, 243, AJC Bose Road, Kolkata-700020. |
| 1.10.2010 – 31.05.2011 | Estrogen and Progesterone Receptor Pattern in Patients of Breast Cancer in India and Its Implication in treatment | Junior Research Fellow | IPGME&R, S.S.K.M. Hospital, 243, AJC Bose Road, Kolkata-700020. |
| 1.06.2011-31.05.2013 | Study of host-tumor interaction in breast cancer with special reference to ER, PR, HER-2/neu, COX-2 , Cyclin D1, beta-catenin and NF-kB | Senior Research Fellow | IPGME&R, S.S.K.M. Hospital, 243, AJC Bose Road, Kolkata-700020. |
| 1.06.2013-31.05.2016 | CA 15-3 as a measure of predicting occult tumor burden in patients with breast cancer | Senior Research Fellow | IPGME&R, S.S.K.M. Hospital, 243, AJC Bose Road, Kolkata-700020. |
| 4.06.2016 to till date | Prognostic significance of miR-34a in respect of NF-kB, p53 expression in different stage/grade of female genital and gonadal cancer | Young Scientist | IPGME&R, S.S.K.M. Hospital, 243, AJC Bose Road, Kolkata-700020. |
Major areas of Research Interest
- Biomarker in cancer biology.
- Molecular targeted therapy in cancer cell.
Metastasis and biochemistry in tumor biology
POPULAR PUBLICATION
Published Manuscripts
Pre-Doctoral Work
1. P. Ghosh, D. Jana, S. Dhar, A. Ghosh. To determine the prevalence and clinically significant cut-off titre of anti-cyclic citrullinated peptide antibody in the diagnosis of early rheumatoid arthritis in Indian population. Indian Journal of Rheumatology, 2011, 6: S2.
2. D. Jana, S. Mandal, M. Mukhopadhyay, D. Mitra, S. K Mukhopadhyay, D. K. Sarkar. Prognostic Significance of HER-2/neu and Survival of Breast Cancer Patients Attending a Specialized Breast Clinic in Kolkata, Eastern India. Asian Pacifc J Cancer Prev, 2012, 13(8):3851-3855. IF:2.52
3. A. Sinha, D.K. Sarkar, S. Ganguly, D. Jana. Kb as a prognostic marker in Breast cancer: A pilot study in Indian patients, Surgical clinics of India SCI, 2012; 2(1).
4. D. Jana, D. K. Sarkar, A. Maji, B. R. Chikkala, S. Hassanujjaman, M. Mukhopadhyay, S. Ganguly. Can cyclo-oxygenase-2 be a useful prognostic and risk stratification marker in breast cancer? J of The Indian Medical Association, 2012, 110(7): 429-433. IF:0.31
5. D. Jana, S. Das, D. K. Sarkar, S. Mandal, A. Maji, M. Mukhopadhyay. Role of Nuclear Factor-κB in female Breast Cancer: A Study in Indian Patients. Asian Pacifc J Cancer Prev, 2012, 13(11):5511-5515.
6. D. K. Sarkar, D. Jana , P. S. Patil, K. S. Chaudhari, B. K. Chattopadhyay, B. R. Chikkala, S. Mandal, P. Chowdhary. Role of NF-κB as a Prognostic Marker in Breast Cancer: A Pilot Study in Indian Patients. Indian J Surg Oncol, 2013, 13: 0234-0238. 0.47
7. D. Jana, D. K. Sarkar, S. Ganguly, S. Saha, G. Sa, A. K. Manna, A. Banerjee, S. Mandal. Role of Cyclooxygenase 2 (COX-2) in Prognosis of Breast Cancer. Indian J Surg Oncol, 2014, 5(1): 59-65.
8. D. Jana, D. K. Sarkar, S. Ganguly, A. K. Manna, A. Banerjee , S. Mandal. Can molecular subtyping replace axillary nodal status as prognostic marker in breast cancer?Indian J Surg Oncol, 2014, 5(4):282-289.
9. D. K. Sarkar, D. Jana, S. Ganguly. Role of NF-κB as a prognostic marker in breast cancer: A pilot study in Indian patients. European Journal of Surgical Oncology, 2014, 40: 632. 3.244
10. D. K. Sarkar, D. Jana, S. Ganguly Can cyclo-oxygenase-2 be a useful prognostic and risk stratification marker in breast cancer? European Journal of Surgical Oncology, 2014, 40: 659.
11. P. K. Sahoo,D. Jana, P. K. Mandal, S.N.Basak. Effect of lymphangiogenesis and lymphovascular invasion in the pattern survival of breast cancer patients. Asian Pacific Journal of Cancer Prevention, 2014, 15 (15): 6287-6293.
12. Saha S, Mukherjee S, MazumdarM, MannaA, KhanP, AdhikaryA, KajalK, JanaD, SaG, MukherjeeS, Sarkar DK, DasT. Mithramycin A sensitizes therapy-resistant breast cancer stem cells towards genotoxic drug doxorubicin. Translational Res.,2015, 165(5):558-577. 5.03
Postdoctoral Work to till date
13. S. Saha, P. Mandal, S. Ganguly, D. Jana, A. Ayaz, A. Banerjee, R. Chouhan, D. K. Sarkar. Decreased expression of BRCA2 accelerates sporadic breast cancer progression. Indian Journal of Surgical Oncology, 2015, 6(4):378-383.
14. S. Saha, S. Mukherjee, P. Khan, K. Kajal, M. Mazumdar, A. Manna, S. Mukherjee, S. De, D. Jana, D. Sarkar, and T. Das. Aspirin suppresses the acquisition of chemo-resistance in breast cancer by disrupting an NFκB-IL6 signaling axis responsible for the generation of cancer stem cells. Cancer Research, 2016 ,76(7):2000-2012. 9.329
15. T. Das, S. Mukherjee, A. Manna, P. Bhattacharjee, M. Mazumdar, S. Saha, S. Chakraborty, D. Guha, A. Adhikary, D. Jana, M. Gorain, S. Mukherjee, G. Kundu, and D. Sarkar. Non-migratory tumorigenic intrinsic cancer stem cells ensure breast cancer metastasis by generation of CXCR4+ migrating cancer stem cells. Oncogene, 2016, 35(37): 4937-4948. 8.459
16. P. Mazumdar, U. K. Das, D. Jana. Oral hygeine maintenance of school going children in West Bengal-a survey study. International Journal of Current Research, 2016, 8(9): 38858-38863. 7.086
17. P. Mazumdar, U. K. Das, D. Jana. Dietary habits of school going children in West Bengal – A cross sectional study. International Journal of Medical and Health Sciences, 2017, 6(1): 12-18. 3.51
18. R. Gupta, S. Chakrabarti, S. Ghosh, D. Jana. Impact of Maternal Nutritional Knowledge on the Anthropometric Parameters of 0-12 years aged Children. PARIPEX – INDIAN JOURNAL OF RESEARCH, 2017, 6(3): 484-486. 5.761
19. R. Gupta, S. Chakrabarti, S. Ghosh, D. Jana. Role of Literacy in Determining the Nutritional Awareness among Mothers of 0-12 years aged Children. Imperial Journal of Interdisciplinary Research, 2017, 3(4): 1728-1733.
20. D. K. Pal, D. K. Bera, D. Jana. Predictive factors of muscle invasiveness in patients undergoing TURBT. Scholars Journal of Applied Medical Sciences, 2017,5(4C):1380-1384.
21. S. Choudhury, S. K. Das, D. Jana, D. K. Pal. Is urodynamic study is a necessity for evaluation of lower urinary tract symptoms in postmenopausal female patients? Result of a prospective observational study. Urology Annals, 2017, 9 (3):239-243.
22. SN Bandyopadhyay, S Banerjee, S K. Mukhopadhayay, D. Jana. Risk of Ovarian Cancer Compare to benign Ovarian Disease among Women in Indian Scenario. International Journal of Scientific Engineering and Research, 2017, 5(8): 73-77. 0.18
23. D. Jana, SN Bandyopadhyay, P. Upadhyay, A. Adhikary, A. K. Manna. ROLE OF P65 AND P53 EXPRESSION IN DIFFERENT STAGE AND GRADE OF OVARIAN CANCER. INDIAN JOURNAL OF APPLIED RESEARCH, 2017, 7(9):59-61.
24. D. Jana, S. Bandyopadhyay, P. Upadhyay, A. Adhikary and A. K. Manna. PROGNOSTICATION OF NF-ΚB AND P53 EXPRESSION IN DIFFERENT STAGE AND GRADE OF OVARIAN CANCER. Int. J. Adv. Res, 2017, 5(8): 603-610.
25. S. N. Basak, P. Kumar and D. Jana. REMOVAL OF INFECTED RESIDUAL MESH IN A RECTOPEXY PATIENT THROUGH ENDO-ANAL PULL THROUGH – AN INNOVATIVE APPROACH. International Journal of Innovative and Applied Research, 2017, 5(8): 61-64.
26. R. Roy, D. K. Sarkar, D. Jana. RISK FACTORS ASSOCIATED WITH BREAST CANCER AND BENIGN BREAST DISEASE AMONG WOMEN IN EASTERN INDIA: A HOSPITAL BASED STUDY. International Journal of Current Research, 2017, 9(8): 55887-55892.
27. S. Bandyopadhyay, S. K. Mondal, T. K. Das and D. Jana. COMPARISON OF SERUM CALCIUM AND MAGNESIUM LEVELS BETWEEN PREECLAMPTIC AND NORMOTENSIVE HEALTHY PREGNANT WOMEN. International Journal of Current Research, 2017, 9 (09): 56951-56957.
ABOUT MY RESEARCH WORK
Epidemiology and biochemical homeostasis in breast cancer:
First phase of my research work to assess epidemiological risk factors includes menopausal status, age at menarche, age at menopause, marital status, parity, duration of lactation, age at first pregnancy, family history of cancer, domicile status, literacy, occupation, use of OCP and BMI associated with breast cancer. Genetic instability caused by decreased expression of BRCA2 could trigger mutations in DNA repair. sporadic breast cancer cases and mutations in turn leads to uncontrolled proliferation and invasive growth. Second phase includes alteration of biochemical homeostasis, abnormal hormone receptor function and abnormal sub-cellular signaling processes, as well as its predictive importance was studied. Estimation of ALP and ALT levels in serum was less sensitive than an imaging procedure, but it may be valuable for screening and early detection for metastases in breast cancer patients.
Prognostic and predictive impact of molecular factors:
NF-κB, COX-2 and β-Catenin overexpression implies aggressive tumour biology in breast cancer & it can predict tumours likely to have a poor prognosis. Patients with NF-κB, COX-2 and β-Catenin positive tumours need to be treated aggressively in our clinical management. Higher percentage of NF-κB /p65, COX-2, β-Catenin positive and CyclinD1 negative patients correlated with different type metastases or recurrence during follow-up. High levels ALP and ALT were observed in liver and bone metastatic breast cancer patients.
Implementation issues of immune targeting therapy:
Only a small proportion of patients in this study were able to afford the trastuzumab, and thereby avail of its benefits due to high cost. But, the majority of the patients were unable to afford the drug, a scenario which is representative of a significant portion of the rural Indian population. Therefore, in spite of substantial benefits of trastuzumab in the survival of patients with breast cancer, its applicability in our setup is limited and demonstrates the need for development of newer low-cost alternatives. Despite intensive clinical research, no β-Catenin inhibitors are available as therapeutic agents yet. Amongst these, inhibitors of COX-2 are being used presently in colorectal cancers, and have been demonstrated to be of use even in patients of Breast Cancer. These inhibitors have provided a low-cost option for decreasing disease progression and prolonging survival. Even though specific COX-2 inhibitors like Celecoxib have faced considerable criticism because of their cardiovascular side effects, non-specific COX-2 inhibitors like Aspirin have been used in many trials successfully without any major side effects. They can be used concurrently with chemotherapy without any adverse effects. If the role of COX-2 can be established with certainty and be incorporated into treatment regimes, it will be a viable alternative to the other expensive modalities of treatment used presently. Effectiveness of mithramycin A was overcomes the instrinsic chemoresistance and self-renewal potential of breast cancer stem cells and to sensitize them to chemotherapeutic drug doxorubicin.
All Past and Current research (Conference Attended) in all countries:
1.Poster presentation at National Conference on “Scope and application of microbes in agriculture and environment” -Phytoremediation of cadmium contaminated soil. Dr. S.Katiyar, R.K Sahu, D.Jana, S.D Tiwari, V.Shukla, A.Sharma, A Katiyar -19th to 21st February, 2007.CSJM University,Kanpur.
2.Poster presentation at National Conference on “Scope and application of microbes in agriculture and environment” –Role of Mycorrhizae in Heavy Metal Contaminated Soil Remediation, S. Katiyar,R.K. Sahu, A. Katiyar, S.Kumar, S.D. Tiwari, M. Baranwal, S. Gupta and D. Jana. 19th to 21st February, 2007.CSJM University,Kanpur.
3.Poster presentation at 79th Annual Meeting of the Society of Biological Chemists(India)-Regulation of Biochemical and Cellular Processes in Diverse Systems- Role of CA15-3 as a Marker for Occult Metastasis of Breast Cancer, Debarshi Jana, Diptendra Kumar Sarkar and SubhadeepMandal, 13-15 December,2010, Indian Institute of Science, Bangalore.
4. Poster presentation at 79th Annual Meeting of the Society of Biological Chemists(India)-Regulation of Biochemical and Cellular Processes in Diverse Systems- Estrogen Receptor Study Useful in Prognostication of Breast Cancer Patients in India, SubhadeepMandal, Diptendra Kumar Sarkar and Debarshi Jana,13-15 December,2010, Indian Institute of Science, Bangalore.
5.18th West Bengal State Science and Technology. Role of HER-2/Neu in Prognostication of Breast Cancer, SubhadeepMandal,Dr. Diptendra K. Sarkar,Debarshi Jana,28th Feb to 1st March, 2011, Narandrapur,Kolkata(Abstract).
6.18th West Bengal State Science and Technology.Role of Estrogen and Progesterone Receptors in Breast Cancer.Debarshi Jana,Dr. Diptendra K. Sarkar, SubhadeepMandal, 28th Feb to 1st March,2011,Narandrapur,Kolkata (Oral presentation)
7. SASICME-2011. Role of Pre-operative serum CA15-3 level in risk stratification of breast cancer in Indian patients, Dr.D.K.Sarkar, Dr.P.Chowdhary, Dr.P.S. Patil, Dr.B.R.Chikala, Debarshi Jana.1st to 3rd September, 2011, Dept. of Surgery,IPGME&R, Kolkata (Paper).
8. Poster presentation at 2nd International Conference on Stem Cells and Cancer(ICSCC-2011) COX-2 Receptor-as Prognostic and Predictive Significance in Breast Cancer, Debarshi Jana, DiptendraK.Sarkar,BitanK.Chattopadhyay,Bhargava Ram,Prashant S Patil-15th -18th Oct-2011,Pune, India (Poster Presentation).
9.5th International Advanced Medicare Congress- Role of CA15-3 as a marker for occult metastasis of breast cancer, Diptendra Kumar Sarkar, SubhadeepMandal, Debarshi Jana. 3rd to 5th December,2011,Golpark, Kolkata.(Abstract)
10.”Challenges and strategies for Veterinary Public Health in India” Milk borne diseases of public health importance and strategies for prevention and control, S.Ganguly, D.Niyogi, I.Ali, D.Kumar, D.Jana, M. Ganguli, G.K.Kumar and S.K.Mukhopadhayay, Febuary-2011, pages 49-57.(Paper Presentation)
11.Tenth CMC Winter Symposium Cellular and Molecular Medicine Cancer, Stem Cells &Inflammation.Role of Cox-2 Receptors in Prognosis of Breast Cancer, Bhargava Ram, DiptendraSarkar, Debarshi Jana, Bitan K. Chatterjee, PrashantPatil, 5th to 7th January,2012, Christian Medical College, Vellore. (Abstract)
12. XXth Annual State Conference IAPM, West Bengal Chapter. NF-kB- As a Prognostic Significance in Breast Cancer, Debarshi Jana, Dr. MadhumitaMukhopadhyay, Dr. Diptendra Kumar Sarkar, Dr.Sunit Kumar Mukhopadhayay, 30th September,2012, Department of Pathology, IPGME&R, Kolkata. Page No-30.(Oral Presentation).
13. 3rd International Conference on Stem Cells and Cancer(ICSCC-2012): Proliferation, Differentiation and Apoptosis. Prognostic Significance of beta-Catenin in Breast Cancer, Debarshi Jana,Diptendra K. Sarkar, SuvroGanguly and ProsenjitChoudhury, 27-30 October, 2012, New Delhi. Page No-140 (Poster Presentation).
14. Poster presentation at 81th Annual Meeting of the Society of Biological Chemists(India) and Symposium on Chemistry and Biology : Two Weapons Against Disease. Can molecular subtyping change lymph nodal status as prognostic marker in breast cancer, Debarshi Jana, Diptendra Kumar Sarkar, Soumen Das, AmitSinha, Syed Hassnujjaman,8-11th November,2012, Science City Auditorium Complex, Kolkata. Page no-165, (Poster Presentation).
15.6th International Advanced Medicare and Forensic Science Medicine Congress. Prognostic Significance of Cyclin D1 in breast Cancer.DEBARSHI JANA, DR. DIPTENDRA K SARKAR, DR. SUNIT K. MUKHOPADHAYAY, 22 to 24 December, 2012, Golpark, Kolkata. Page No-34-38. (Oral Presentation)
16. Poster presentation at 57th All India Annual Conference of IPHA & South-East Asia Regional Public Health Conference. Role of beta-Catenin in female Breast Cancer: A study in Indian patients .DebarshiJana, Dr.Sunit K Mukhopadhayay, Dr.DiptendraK.Sarkar. , 01 to 03rd February-2013, Science City, Kolkata. Page No-07, (Poster Presentation).
17. 20th West Bengal State Science and Technology. Molecular Subtypes as prognostic factor in Breast Cancer.DEBARSHI JANA, DR. DIPTENDRA KUMAR SARKAR, DR. SOUMEN DAS, DR. SUNIT K. MUKHOPADHAYAY. 28th February to 2nd March, 2013. Bengal Engineering and Science University, Shibpur, West Bengal. Page no- 249(Oral Presentation)
18. 1st Indian Cancer Congress. Role of cyclinD1 as a prognostic marker in breast cancer.Jana D, Sarkar DK, Ganguly S. 21st to 24th November 2013, New Delhi, Page no- S219, Abstract Id:997 (Poster Presentation).
19. 1st Indian Cancer Congress. p65 overexpression as a marker for prognosticating female breast cancer: A study in Indian patients. Jana D, Sarkar DK, Ganguly S, Banerjee A. 21st to 24th November 2013, New Delhi, Page no- S219, Abstract Id:999 (Poster Presentation).
20. World Science Congress. Prognostic significance and predictive outcome of beta-Catenin overexpression in breast cancer.Debarshi Jana, Diptendra Kumar Sarkar, Sunit K. Mukopadhayay, SyamsundarMandal. 13th to 14th December, 2013, Jadavpur University, Page no-56-58 (Oral Presentation).
21. 3rd Annual Conference (ABSICON -2014). PROGNOSTIC SIGNIFICANCE OF WAIST-HIP RATIO AND OTHER PARAMETERS IN BREAST CANCER.MoumitaChakraborty, Dr. Diptendra K Sarkar, Dr. SuvroGanguly, Debarshi Jana. 13-15 June, 2014, Fortune Park, Howrah, West Bengal, India (Poster Presentation).
22. 3rd Annual Conference (ABSICON -2014).Cyclin D1 be a useful prognostic marker in breast cancer patients. Debarshi Jana, Dr. Diptendra K Sarkar, Dr. SuvroGanguly. 13-15 June, 2014, Fortune Park, Howrah, West Bengal, India (Poster Presentation).
23.7th National Science Conference (World Science Congress).Biochemical Homeostasis and its Alteration in Breast Cancer Patients.Dr.Debarshi Jana, Dr. Diptendra K Sarkar, Dr. Sunit K. Mukhopadhayay.28thFeb to 1stMarch 2015, Jadavpur University, Page no-13(Oral Presentation).
24. ISMPOCON-2016.Prognostic significance of NF-kB expression in different stage/grade of ovarian cancer.Dr.Debarshi Jana, Dr. Sambhunath Bandyopadhyay. 5th to 6th Nov, New Delhi, India (Poster Presentation).
25. ISMPOCON-2016, Prognostic significance of p53 expression in cervical cancer. Piyali Jana Dr.Debarshi Jana. 5th to 6th Nov, New Delhi, India (Poster Presentation).
26. 7th World Ayurveda Congress-2016. Prognostic significance of p53 expression in curcumin induced genital cancer. Dr. Debarshi Jana. 1-4th Dec 2016, Science City, Kolkata, West Bengal (Oral Presentation).
27. Medical, Medicine and Health Sciences-2017. Prognostic significance of NF-kB and p53 expression in different stage and grade of ovarian cancer.Dr.Debarshi Jana, Dr. Sambhunath Bandyopadhyay, Dr. Sunit K. Mukhopadhayay. Holliday Inn Bangkok Silom, Thailand April 17-18, 2017.